Measure twice, cut once: Increasing the precision of size matching in lung transplantation

Size matching in lung transplantation using predicted total lung capacity.

Height is used in allocation of donor lungs as an indirect estimate of thoracic size. Total lung capacity (TLC), determined by both height and sex, could be a more accurate functional estimation of thoracic size. Size-matching criteria based on height versus predicted TLC was retrospectively evaluated, and, furthermore, whether a TLC mismatch was related to clinical and functional complications...

Measure twice, cut once: attachment theory and the NICHD Study of Early Child Care and Youth Development.

The NICHD Early Child Care Research Network has produced research findings that provide reassuring confirmation of some central tenets of attachment theory, challenges to other aspects of the theory, and above all highlight the need for attachment researchers to clarify the claims for which the theory can be held accountable. This commentary on Friedman and Boyle's excellent review evaluates th...

Re: Measure once or twice--does it really matter?

The editorial (1) on our article (2) makes a number of points, and we wish to address these with some further explanation. The first clarification concerns our theoretical section. Our argument is, in fact, more pragmatic rather than mathematical and is indeed the point that the editorial identifies as " largely due to difference in scales. " From its definition as an x% reduction, any measure ...

Biaxial distension of precision-cut lung slices.

The mechanical forces acting on lung parenchyma during (mechanical) ventilation and its (patho)physiological consequences are currently under intense scrutiny. Several in vivo and cell culture models have been developed to study the pulmonary responses to mechanical stretch. While providing extremely useful information, these models do also suffer from limitations in being either too complex fo...

Once bitten, twice shy.